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Red clover, chaste berry, and black cohosh are commonly used folk herbs in Europe and America. Both red clover and chaste berry contain phytoestrogens that can bind to estrogen receptor and regulate the gene expression of estrogen and progesterone receptors, thus are used for hot flash and night sweats of menopause women. Black cohosh can act on serotonin receptors, thereby regulating function of the nervous system and improving symptoms such as anxiety and depression. Unlike the synthetic estrogens, there is no research report on phytoestrogens causing breast cancer or heart disease yet so far.

A Research by Dr. Willow

The Red clover, Chaste Berry, Black cohosh are used as main ingredients these three herbs screened out in the UIC/NIH Center for Botanical Dietary Supplement Research in Women's Health when Dr. Liu was at Illinois State University Chicago.

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